Title:
野性型およびキメラのインフルエンザウイルス様粒子(VLP)のアセンブリー
Document Type and Number:
Japanese Patent JP5008244
Kind Code:
B2
Abstract:
Influenza virus-like particles (VLPs) comprising the structural proteins HA, NA, M1 and M2 are described. VLPs are also generated containing M1 alone, as are VLPs with M1 and any one or two of HA, NA and M2. VLPs with HA from one influenza subtype and NA from a different influenza subtype are also described, as are VLPs in which a portion or all of HA or NA is replaced by a heterologous moiety not produced by influenza virus, so as to comprise chimeric VLPs.
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Inventors:
Galaza, Josem
Ratham, Teresa Y
Ratham, Teresa Y
Application Number:
JP2002506200A
Publication Date:
August 22, 2012
Filing Date:
June 21, 2001
Export Citation:
Assignee:
Wyeth Holdings Corporation
International Classes:
C12N15/09; C12P21/02; A61K39/145; A61K39/39; A61P31/16; C07K14/11; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/04; C12N15/44
Other References:
J. Virol., 70[8] (1996) p.5016-5024
J. Virol., 74[1] (2000-Jan) p.547-551
J. Gen. Virol., 80[7](1999) p.1635-1645
J. Virol., 70[10](1996) p.6653-6657
J. Virol., 70[2](1996) p.873-879
日本臨床, 55[10](1997) p.2581-2586
J. Virol., 74[1] (2000-Jan) p.547-551
J. Gen. Virol., 80[7](1999) p.1635-1645
J. Virol., 70[10](1996) p.6653-6657
J. Virol., 70[2](1996) p.873-879
日本臨床, 55[10](1997) p.2581-2586
Attorney, Agent or Firm:
Patent business corporation Odashima patent office