Title:
コラーゲン産生増強剤
Document Type and Number:
Japanese Patent JP5834297
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a tendon and/or ligament cell differentiation-inducing agent, and to provide a medicine containing the differentiation-inducing agent to prevent or treat diseases related to tendon or ligament.SOLUTION: The agent for inducing differentiation from cells having an ability for differentiating into tendon and/or ligament cells into the tendon and/or ligament cells contains, as an active ingredient, at least one of (A) Mkx protein, (B) a mutant which has at least one mutation selected from the group consisting of the deletion, replacement, movement, addition and insertion of one to several amino acids in the amino acid sequence of the Mkx protein and has an activity for inducing from cells having an ability for differentiating into tendon and/or ligament cells, (C) a nucleic acid encoding the protein of (A) or (B), and (D) an expression vector containing the nucleic acid (C).
Inventors:
Hiroshi Asahara
Yoshiaki Ito
Yoshiaki Ito
Application Number:
JP2010076625A
Publication Date:
December 16, 2015
Filing Date:
March 30, 2010
Export Citation:
Assignee:
Human Science Foundation
International Classes:
C12N5/10; A61K35/12; A61K35/28; A61K35/32; A61K35/33; A61K35/48; A61K35/54; A61K35/545; A61K35/76; A61K35/761; A61K38/00; A61K48/00; A61P19/00; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/68
Other References:
Dev. Dyn.,2006年 3月,Vol.235, No.3,p.792-801
J. Biol. Chem.,2007年 6月15日,Vol.282, No.24,p.17665-17675
Gene Expr. Patterns,2006年 8月,Vol.6, No.6,p.632-636
J. Biol. Chem.,2007年 6月15日,Vol.282, No.24,p.17665-17675
Gene Expr. Patterns,2006年 8月,Vol.6, No.6,p.632-636
Attorney, Agent or Firm:
Maeda patent office
Shinsuke Nakajima
Shinsuke Nakajima