Title:
多能性幹細胞から免疫細胞療法用Ｔ細胞を誘導する方法
Document Type and Number:
Japanese Patent JP6715482
Kind Code:
B2
Abstract:
Provided is a method for inducing T cells for a cell-based immunotherapy, comprising the steps of:
(1) providing Rag 1 and/or Rag2 gene knockout human pluripotent stem cells bearing genes encoding a T cell receptor specific for a desired antigen, and
(2) inducing T cells from the pluripotent stem cells of step (1). Further provided are a cell-based immunotherapy method that uses the T cells for the cell-based immunotherapy and an iPS cell bank for the cell-based immunotherapy.
Inventors:
Kaneko Shin
Hiroshi Kawamoto
Takako Masuda
Atsushi Minamikawa
Hotta Akitsu
Shimazu Yu
Tadashi Ichinose
Hiroshi Kawamoto
Takako Masuda
Atsushi Minamikawa
Hotta Akitsu
Shimazu Yu
Tadashi Ichinose
Application Number:
JP2016534507A
Publication Date:
July 01, 2020
Filing Date:
July 17, 2015
Export Citation:
Assignee:
Kyoto University
Thyas Co., Ltd.
Thyas Co., Ltd.
International Classes:
C12N5/10; A61K35/17; A61P31/00; A61P35/00; A61P37/02; C12N5/0735; C12N5/0783; C12N15/09
Foreign References:
| WO2013176197A1 |
Other References:
HALE J.S. et al.,The Journal of Immunology, 2010, Vol.184, pp.5964-5968
WATANABE K. et al.,Biomedical Research, 2013, Vol.34, No.1, pp.41-50
中島 文明,血液フロンティア, 2013, Vol.23, No.8, pp.1105-1110
TURKA L.A. et al.,Science, 1991, Vol.253, pp.778-781
SHINKAI Y. et al.,Cell, 1992, Vol.68, pp.855-867
MOMBAERTS P. et al.,Cell, 1992, Vol.68, pp.869-877
Cell Stem Cell, 2013, Vol.12, pp.114-126
WATANABE K. et al.,Biomedical Research, 2013, Vol.34, No.1, pp.41-50
中島 文明,血液フロンティア, 2013, Vol.23, No.8, pp.1105-1110
TURKA L.A. et al.,Science, 1991, Vol.253, pp.778-781
SHINKAI Y. et al.,Cell, 1992, Vol.68, pp.855-867
MOMBAERTS P. et al.,Cell, 1992, Vol.68, pp.869-877
Cell Stem Cell, 2013, Vol.12, pp.114-126
Attorney, Agent or Firm:
Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Aoyama Aoi
Michiko Matsutani