Title:
４−フルオロイソキノリンの製法
Document Type and Number:
Japanese Patent JP6755775
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method capable of producing 4-fluoroisoquinoline more simply and in a shorter time compared to heretofore known methods.SOLUTION: Provided is a method for producing 4-fluoroisoquinoline represented by formula (1), where 1-chloro-4-fluoroisoquinoline represented by formula (9a) is reductively decomposed preferably in the presence of a palladium catalyst. Also provided is the method, where 1-chloro-4-fluoroisoquinoline represented by formula (9a) is obtained by treating 1-hydroxyisoquinoline with a fluorinating agent to obtain 4-fluoro-1-hydroxy-3-methoxy-3,4-dihydroxyisoquinoline, which is reacted with a chlorinating agent.SELECTED DRAWING: None
Inventors:
Otsuka Akira
Tetsuya Sakurada
Tetsuya Sakurada
Application Number:
JP2016216053A
Publication Date:
September 16, 2020
Filing Date:
November 04, 2016
Export Citation:
Assignee:
Fujiamide Chemical Co., Ltd.
International Classes:
C07D217/22
Domestic Patent References:
| JP2012516831A | ||||
| JP2010526130A | ||||
| JP2008525406A | ||||
| JP2006273860A | ||||
| JP63211267A |
Foreign References:
| WO2008105442A1 | ||||
| WO2011013644A1 | ||||
| WO2013184734A1 | ||||
| WO1997028130A1 |
Other References:
DATABASE REGISTRY [ONLINE] Retrieved from STN,検索日:2020年1月24日,Entered STN: 19 Jun 2016,CAS登録番号:1934536-53-4
IN 2005MU00436 A
PRICE, David A. et al.,Selective fluorination of 1-hydroxyisoquinolines using Selectfluor,Tetrahedron Letters,2007年,48(41),pp. 7371-7373
IN 2005MU00436 A
PRICE, David A. et al.,Selective fluorination of 1-hydroxyisoquinolines using Selectfluor,Tetrahedron Letters,2007年,48(41),pp. 7371-7373
Attorney, Agent or Firm:
Ono International Patent Office