Title:
癌型ＳＬＣＯ１Ｂ３を標的とする核酸医薬
Document Type and Number:
Japanese Patent JP6823320
Kind Code:
B2
Abstract:
The purpose of the present invention is to: identify a molecule that is expressed in cancer cells but not expressed or only expressed at a very low level in normal cells, and that contributes toward the onset and/or progress of cancer; and provide a substance or the like that inhibits the function or expression of the molecule. The present invention addresses the problem by providing a double-stranded nucleic acid or the like that reduces the expression of the cancer-type solute carrier organic anion transporter family member 1B3.
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Inventors:
Kazutake Tsujikawa
Yuko Ueda
Masayoshi Sat
Yoshihiro Nakamura
Tatsuhiko Furukawa
Yuko Ueda
Masayoshi Sat
Yoshihiro Nakamura
Tatsuhiko Furukawa
Application Number:
JP2017522232A
Publication Date:
February 03, 2021
Filing Date:
June 02, 2016
Export Citation:
Assignee:
National University Corporation Osaka University
National University Corporation Kagoshima University
National University Corporation Kagoshima University
International Classes:
A61K31/713; A61K48/00; A61P35/00; A61P35/04; C12N15/113
Domestic Patent References:
| JP2011188853A |
Other References:
HOSAKA Seiji et al.,Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer,Cancer Sci,2006年,vol.97 no.7,p.623-632
Thakkar Nilay et al.,A Cancer-Specific Variant of the SLCO1B3 Gene Encodes a Novel Human Organic Anion Transporting Polyp,Molecular Pharmaceutics,2013年,vol.10,p.406-416
Thakkar Nilay et al.,A Cancer-Specific Variant of the SLCO1B3 Gene Encodes a Novel Human Organic Anion Transporting Polyp,Molecular Pharmaceutics,2013年,vol.10,p.406-416
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki