癌を治療するためのマクロ環状ＭＣＬ１阻害剤

Title:

癌を治療するためのマクロ環状ＭＣＬ１阻害剤

Document Type and Number:

Japanese Patent JP6894449

Kind Code:

B2

Abstract:

Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I)and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.14,7.011,15.016,21.020,24.030,35]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.

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Inventors:

Alexander Hard
Matthew Alan Belmonte
Wen Jiang Yang
John Paul Seccrist
Daniel William Robbins
Steven Lee Kazmersky
Daedong Woo
Bow Pen
Jeffrey Johannes
Michelle Laurey Lamb
Chin Ye
Jen Xiao Lan

Application Number:

JP2018553226A

Publication Date:

June 30, 2021

Filing Date:

April 21, 2017

Export Citation:

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