Japanese Patent JPH0220639

B2

The invention relates to compounds of the general formula (I) (I) and physiologically acceptable salts, N-oxides, hydrates and bioprecursors thereof, in which Y represents =O, =S, =CHNO2 or =NR3 where R3 represents hydrogen, nitro, cyano, lower alkyl, aryl, lower alkylsulphonyl or arylsulphonyl; R1 and R2, which may be the same or different, each represent hydrogen lower alkyl, cycloalkyl, lower alkenyl, aralkyl, hydroxy, lower trifluoroalkyl, lower alkyl substituted by hydroxy, lower alkoxy, amine, lower alkylamino or dialkylamino, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring which may contain other heteroatoms or the group where R4 represents hydrogen or lower alkyl; Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2- and 5-positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1- and 3- or 1- and 4-positions; X represents -CH2, -O- or -S-; n represents zero, 1 or 2; m represents 2, 3 or 4; Alk represents a straight chain alkylene group of 1 to 3 carbon atoms; (except that n is not zero when X is oxygen and Q is a furan or thiophen ring system) q represents 2, 3 or 4 or can additionally represent zero or 1 when E is a -CH2-group; p represents zero, 1 or 2; E represents -CH2-, -O- or -S-; and Z represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring which may be optionally substituted by one or more groups or Z represents the group where Q' represents any of the rings defined for Q; Alk' represents any of the groups defined for Alk; and R5 and R6, which may be the same or different, each represent any of the groups defined for R1 and R2; (except that p is not zero when E is oxygen and Q' or Z is a furan or thiophen ring system). The compounds of formula (I) show pharmacological activity as selective histamine H2-antagonists.

WO/2002/048131	ARYLATED FURANE AND THIOPHENE CARBOXYLIC ACID AMIDES WITH POTASSIUM CHANNEL BLOCKING EFFECT
JPS62153282	6-(1,4,5,8-TETRAMETHOXYNAPHTAHLEN-2-YL)-3,4,5,6-TETRAHYDRO-2H-PYRAN DERIVATIVE
WO/2003/049746	COMBINATION OF CYTOCHOME P¿450? DEPENDENT PROTEASE INHIBITORS

MAIKERU MAACHIN SUMISU
BARII JON PURAISU
JON BURATSUDOSHOO
JON WATOSON KURIZEROO

JP16439178A

May 10, 1990

December 23, 1978

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GLAXO GROUP LTD

A61K31/34; A61K31/341; A61K31/345; A61K31/38; A61K31/381; A61K31/40; A61K31/495; A61K31/505; A61P1/04; C07C67/00; C07C209/00; C07C209/60; C07C211/29; C07C217/48; C07C261/04; C07C275/32; C07C301/00; C07C303/36; C07C303/40; C07C311/64; C07C313/00; C07C323/29; C07C323/44; C07C323/47; C07C323/48; C07C325/00; C07C335/08; C07D209/48; C07D213/32; C07D295/096; C07D307/28; C07D307/38; C07D307/52; C07D333/20; C07D405/12; C07D409/12

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