Japanese Patent JPH0262547

B2

The invention relates to a guanidine of the formula:- in which R<1> and R<2> are H, C1-10 alkyl, C3-8 cycloalkyl or cycloalkylalkyl in which the alkyl part is C1-6 and the cycloalkyl part is C3-8, each of the alkyl, cycloalkyl and cycloalkylalkyls being optionally substituted by one or more halogens selected from F, Cl and Br, provided that at least one of R<1> and R<2> is a halogen substituted alkyl, cycloalkyl or cycloalkyl-alkyl and provided that there is no halogen substituent on the carbon directly attached to the nitrogen; ring X is phenyl carrying 1 or 2 optional substitutents or a 5- or 6-membered heterocyclic aromatic ring containing 1, 2 or 3 hetero atoms selected from O, N and S, which heterocyclic ring may, carry a single optional substituent selected from F, Cl, Br, I, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, trifluoromethyl, hydroxy and amino; Y is O, S, a direct bond, methylene, vinylene, SO or NR<4> in which R<4> is H or C1-6 alkyl; m is 0 to 4 and n is 1 to 5, provided that when Y is O, SO or NR<4>, n is 2 to 5; R<3> has various significances; and the pharmaceutically-acceptable acid-addition salts thereof. Manufacturing processes and pharmaceutical compositions are also described.

TOBIASU OREGON IERIN
FUIRITSUPU NERU EDOWAAZU
MAIKURU SUTEYUWAATO RAAJI

JP30228189A

December 26, 1990

November 22, 1989

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IMUPERIARU CHEM IND PLC
AI SHII AI AMERIKA INC

C07D251/16; C07C279/18; C07C323/44; C07C335/28; C07D209/48; C07D213/74; C07D213/75; C07D231/38; C07D231/40; C07D239/42; C07D239/46; C07D239/47; C07D239/48; C07D241/20; C07D251/18; C07D277/20; C07D277/42; C07D277/48; C07D285/08; C07D403/12; C07D417/12; G09F13/04

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