Title:
【発明の名称】血液脳関門を経る治療薬の分別送達
Document Type and Number:
Japanese Patent JPH03503632
Kind Code:
A
Abstract:
A method for the delivery of therapeutic agents across the blood brain barrier is disclosed which utilizes drug neutralization technology, and the selective permeability of the blood brain barrier (BBB). During and after the formation of brain lesions, the BBB becomes increasingly permeable. To treat these conditions, a therapeutically effective amount of a selected drug is administered having a molecular weight and other characteristics allowing passage of the drug through the modified BBB. Thereafter, a neutralizing material specific to the drug is administered. The neutralizing material has a high molecular weight and/or some other characteristic(s) which prevent its passage through the modified BBB. The neutralizing material binds to or reacts with the excess drug circulating outside the BBB, in order to prevent the manifestation of drug toxicity problems.
Inventors:
New Welt Edward A
Application Number:
JP50056388A
Publication Date:
August 15, 1991
Filing Date:
November 17, 1988
Export Citation:
Assignee:
State Of Oregon Acting By And Through The State Board Of Higher Education On Bihalf Of Oregon Health Sciences University
International Classes:
A61K45/06; A61K31/70; A61K39/395; A61K47/48; A61P9/00; A61P35/00; C07K16/44; A61K38/00; (IPC1-7): A61K31/70; A61K39/395; A61K45/06
Attorney, Agent or Firm:
Akihide Sugimura (1 outside)