Title:
【発明の名称】遺伝物質を血液脳関門に送る方法
Document Type and Number:
Japanese Patent JPH03503633
Kind Code:
A
Abstract:
A method for treating genetic and acquired brain disorders is disclosed in which genetic material is introduced into the blood stream for delivery to the brain. Prior to delivery, the interendothelial structure of the BBB is chemically altered to permit passage of the genetic material therethrough. This is accomplished through osmotic disruption of the BBB by administration of suitable chemical agents. Prior to administration, the genetic material can be inserted within the genome of a viral vector preferably incapable of replication in vivo. After crossing the blood brian barrier, the vector containing the genetic material enters the brain tissues where it delivers in a site-specific manner the genetic material in order to control adverse effects of the disease caused by defective genes. After delivery of the genetic material, the replication-defective character of the viral vector prevents its reproduction.
Inventors:
New Welt Edward A
Application Number:
JP50097889A
Publication Date:
August 15, 1991
Filing Date:
November 18, 1988
Export Citation:
Assignee:
State Of Oregon Acting By And Through The State Board Of Higher Education On Bihalf Of Oregon Health Sciences University
International Classes:
C12N15/00; A61K48/00; A61P25/28; (IPC1-7): A61K48/00; C12N15/86
Attorney, Agent or Firm:
Akihide Sugimura (1 outside)