Title:
【発明の名称】癌治療に有用であり、かつ抗ヒスタミン特性を有する医薬
Document Type and Number:
Japanese Patent JPH04506072
Kind Code:
A
Abstract:
Use of compounds of formula (I) wherein A represents a group selected from: X represents -CH- or -N-; R<1> represents a hydrogen or halogen atom, a C1-4 alkoxy group, a C1-4 alkyl group, or a C1-4 alkyl group substituted by 1 to 3 halogen atoms; R<2> represents a hydrogen or halogen atom, a C1-4 alkoxy group, benzyloxy or a group -R<7>COOR<8> (wherein R<7> represents a single bond or a C1-7 bivalent aliphatic hydrocarbon group and R<8> represents a hydrogen atom or a C1-4 alkyl group) or a group R<7>CONR<8a>R<8b> (wherein R<8a> and R<8b> each represent a hydrogen atom or a C1-4 alkyl group, or together with the nitrogen atom to which they are attached form a 4-6 membered saturated heterocyclic ring); R<3> and R<4>, which may be the same or different each represent a hydrogen atom or a C1-4 alkyl group, or R<3> and R<4> together with the nitrogen atom to which they are attached form a 4-6 membered saturated heterocyclic ring, which may optionally contain an oxygen atom or a further nitrogen atom, which may itself be substituted by a C1-4 alkyl group; R<5> and R<6> each represent a hydrogen atom or together form a linking group between the aromatic rings, said group being selected from -CH2CH2-, -CH2O-, -OCH2-, -NHCH2, or -CH2NH; n is zero or an integer from 1 to 3; and p and q are each independently an integer from 1 to 4, with the provisos that (a) when R<5> and R<6> form a linking group, A is not -CH2 @-(CH2)n- and (b) when A represents a group @ @C=CH(CH2)n- and n is 1, R<1> is methyl, NR<3>R<4> is pyrrolidino and R<5> and R<6> are both hydrogen then R<2> is not hydrogen or -CH=CHCO2H, and pharmaceutically acceptable salts thereof in the manufacture of a medicament for enhancing the therapeutic effect of an antineoplastic agent.
Inventors:
Lever, Oscar William
King, Anne Christie
Hafenist Morton
Chao, Esser Yuhusuan
King, Anne Christie
Hafenist Morton
Chao, Esser Yuhusuan
Application Number:
JP50865990A
Publication Date:
October 22, 1992
Filing Date:
June 18, 1990
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
A61K31/00; A61K31/13; A61K31/135; A61K31/165; A61K31/19; A61K31/215; A61K31/235; A61K31/24; A61K31/33; A61K31/335; A61K31/395; A61K31/40; A61K31/44; A61K31/495; A61K31/54; A61K31/55; A61K45/06; A61P35/00; A61P43/00; C07C211/32; A61K31/16; C07C229/34; C07C229/38; C07C237/30; C07D213/38; C07D213/55; C07D213/56; C07D295/06; C07D295/073; C07D295/096; C07D295/14; C07D295/155; C07D313/00; C07D313/12; (IPC1-7): A61K31/16; A61K31/165; A61K31/19; A61K31/215; A61K31/235; A61K31/24; A61K31/335; A61K31/40; A61K31/495; A61K31/54; A61K31/55; A61K45/06; C07C211/32; C07C229/34; C07C229/38; C07C237/30; C07D213/38; C07D295/06; C07D295/14; C07D313/12
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)