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Document Type and Number:
Japanese Patent JPH0552309
Kind Code:
B2
Abstract:
Compounds of the formulawherein C' and N4 are in trans configuration to each other, Y is OH, R'COO, R2R3NCOO- or R4O whereby R' is an aliphatic hydrocarbon residue having 1-17 carbon atoms, a phenyl, 2,6-dimethylphenyl or 3- or 4-hydroxyphenyl group or a 3- or 4-alkanoyloxyphenyl group with the formula wherein R5 is an alkyl group having 1-6 carbon atoms, or R' is a groupwherein R6 is hydrogen, an alkyl group having 1 to 5 carbon atoms or a phenyl group, R7 is hydrogen, an alkyl group having 1 to 5 carbon atoms or an acyl group and R8 is hydrogen or an alkyl group having 1 to 5 carbon atoms, R2 is hydrogen, an alkyl group having 1-5 carbon atoms, a phenethyl, benzyl or phenyl group which may be mono- or disubstituted in the aromatic part with a methyl, methoxy, hydroxy, nitro or cyano group or a halogen, R' is H, an alkyl group having 1 to 5 carbon atoms or a phenyl group or R2 and R3 together with the nitrogen atom form a 5, 6 or membered ring that may contain 1 to 3 double bonds and/or 1 or further hetero-atoms selected from N, 0 and S, and R4 is an allyl or benzyl group and R is hydrogen or the groupwherein n is 3 or 4 and R9 is hydrogen, an alkanoyl group having 2-6 carbon atoms or benzoyl, as bases and pharmaceutically acceptable acid addition salts thereof, processes for their preparation and pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for treatment of disorders in the central nervous system.

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Inventors:
ANDERUSON BENKUTO RONNII
ARUIDOSON FUORUKE RARUSUUERIIK
KAARUSON PERU AAUITSUDO EMIIRU
YORUTO YOON SUTEFUAN MIKAERU
YOHANSON ANETSUTE MAAGAREETA
RINDOBERUI PERU RENAATO
NIRUSON YOON RARUSU GUNNAA
SAN
Application Number:
JP50179184A
Publication Date:
August 05, 1993
Filing Date:
April 12, 1984
Export Citation:
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Assignee:
PERU AAUITSUDO EMIIRU KAARUSON
International Classes:
A61K31/435; A61P25/00; C07D221/10; C07D401/12; C07D413/12; C07D417/12; C07D419/12; C07D; (IPC1-7): C07D221/10; A61K31/435



 
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