Title:
【発明の名称】サイトカインの産生および分泌を阻害する製薬学的組成物
Document Type and Number:
Japanese Patent JP2002542188
Kind Code:
A
Abstract:
Pharmaceutical compositions incorporate compounds that affect cytokine production and/or secretion. Such compounds include aryl substituted olefinic amine compounds, pyridyloxylalkylamines and phenoxyalkylamines, and aryl substituted amine compounds, such as 3-aminophenyl amine compounds. Such pharmaceutical compositions can be used for treating a wide variety of conditions, diseases and disorders, and particularly those associated with dysfunction of cytokine production and/or secretion. Of particular interest are pharmaceutical compositions useful for preventing and treating conditions, diseases and disorders associated with undesirably high levels of cytokine production and/or secretion. Such pharmaceutical compositions are useful for treating the effects of inflammatory bowel disease, inflammation, arthritis, cachexia in neoplastics diseases or associated with AIDS, and autoimmune diseases.
Inventors:
Benkeriff, Meroane
Application Number:
JP2000611904A
Publication Date:
December 10, 2002
Filing Date:
April 20, 2000
Export Citation:
Assignee:
Targacept, Incorporated
International Classes:
C07D213/38; A61K31/00; A61K31/138; A61K31/435; A61K31/4406; A61K31/4412; A61K31/505; A61K31/513; A61P1/04; A61P1/14; A61P3/00; A61P17/02; A61P29/00; A61P29/02; A61P31/00; A61P31/18; A61P33/06; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07D213/65; (IPC1-7): A61K31/138; A61K31/4406; A61P1/04; A61P1/14; A61P3/00; A61P17/02; A61P29/00; A61P31/00; A61P31/18; A61P33/06; A61P35/00; A61P37/02; A61P43/00; C07D213/38
Domestic Patent References:
| JPH10512857A | 1998-12-08 |
Foreign References:
| WO1997040011A1 | 1997-10-30 |
Attorney, Agent or Firm:
Okuyama Shoichi (2 outside)