Document Type and Number:
Japanese Patent JPH0564144
Kind Code:
B2
Abstract:
Novel fused 7-membered ring compounds represented by the following formula (I), wherein R<1> and R<2> each represents hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy or, when taken together, they represent tri- or tetra-methylene, R<3> represents hydrogen, lower alkyl or aralkyl, R<4> represents hydrogen, alkyl or optionally substituted aralkyl or cycloalkyl, and X represents S(0)n (wherein n represents an integer of 0 to 2), Y represents an optionally esterified or amidated carboxyl group, and m represents 1 or 2, and the salts thereof. These compounds have an effect of inhibiting angiotensin-converting enzyme, and are useful for diagnosis, prophylaxis or treatment of hypertension.
More Like This:
| JPS59152374 | BENZAZEPINE DERIVATIVES |
| JP5903092 | Anti-abuse gel-like pharmaceutical composition |
| JPH02174716 | PERCUTANEOUS PREPARATION |
Inventors:
SUGIHARA HIROSADA
NISHIKAWA KOHEI
ITO KATSUMI
NISHIKAWA KOHEI
ITO KATSUMI
Application Number:
JP7999684A
Publication Date:
September 14, 1993
Filing Date:
April 19, 1984
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K31/55; A61K31/554; A61K38/00; A61P9/00; A61P9/12; A61P43/00; C07D209/48; C07D281/10; C07D417/04; C07K5/02; C07K5/06; C07K14/81; (IPC1-7): C07D281/10; A61K31/55; A61K37/02; C07K5/06