Japanese Patent JPH0573749

B2

PURPOSE:To economically obtain the titled compound useful as a hypotensor, a cerebral or coronary vasodilator and a platelet coagulation inhibitor, by alkylating 4-hydroxyphenyl group of a compound corresponding to the titled compound to 4-alkoxyphenyl group. CONSTITUTION:The compound of formula II (R<1> is lower alkyl R<2> is H or lower alkanoyl X<1> is H or lower alkyl) or its salt useful for the remedy amelio ration or prevention of cerebral diseases such as hypertension, cerebrovascular contraction, etc., cardiac diseases such as stenocardia or thromotic diseases such as cerebral thrombosis, etc., can be produced by alkylating the compound of formula I (R<3> is H or lower alkanoyl X<2> is H, alkyl or protecting group), removing X<2> when it is a protecting group, optionally removing R<3> when it is lower alkanolyl group and optionally converting the product to its salt. Since the reaction can be performed without causing racemization, an optical isomer can be produced by using an optically active raw material.

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INOE HIROZUMI
OOTSUKA HISAO

JP184586A

October 15, 1993

January 07, 1986

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TANABE SEIYAKU CO

A61K31/55; C07D281/10; A61K31/554; C07D221/10; C07D281/00; C07D281/02; C07D417/04; C07D; (IPC1-7): C07D281/10

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