Title:
【発明の名称】特定アミノメチルフェニルイミダゾール誘導体、新種のドーパミン受容体サブタイプの特定リガンド
Document Type and Number:
Japanese Patent JPH06504054
Kind Code:
A
Abstract:
PCT No. PCT/US91/09816 Sec. 371 Date Nov. 8, 1993 Sec. 102(e) Date Nov. 8, 1993 PCT Filed Dec. 23, 1991.This invention encompasses compounds of the formulas: where R1, R3, R4, R6, X, Y, and Z are T are variables; and M is or gether may represent -(CH2)n1 where n1 is 1, 2, or 3. These compounds are highly selective partial agonists or antagonists at brain dopamine receptor subtypes or prodrugs thereof and are useful in the diagnosis and treatment of affective disorders such as schizophrenia and depression as well as certain movement disorders such as Parkinsonism. Furthermore compounds of this invention may be useful in treating the extraparamidyl side effects associated with the use of conventional neuroleptic agents.
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Inventors:
Salkauf, Andrew Wy.
Hatchson, Alan Jay.
Hatchson, Alan Jay.
Application Number:
JP50322691A
Publication Date:
May 12, 1994
Filing Date:
December 23, 1991
Export Citation:
Assignee:
NEUROGEN CORPORATION
International Classes:
A61K31/415; A61K31/44; A61K31/4427; A61K31/445; A61K31/47; A61K31/495; A61K31/505; A61K31/55; A61P25/00; A61P25/24; A61P25/26; C07D233/54; C07D233/64; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D403/14; (IPC1-7): C07D233/64; A61K31/415; A61K31/44; A61K31/445; A61K31/495; A61K31/55; C07D401/12; C07D401/14; C07D403/12; C07D403/14
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)