Title:
【発明の名称】5-HT▲下4▼レセプターアンタゴニスト用複素環式縮合安息香酸誘導体
Document Type and Number:
Japanese Patent JPH08502275
Kind Code:
A
Abstract:
A morphinan derivative represented by the general formula (I) or its pharmacologically acceptable acid addition salt: wherein R<5> is a specified cyclic ring, B is C1-14 alkylene and A is -XC(=Y)-, -XC(=y)z-, -X-, -XSO2- or -OC(OR<4>)(R<4>)- (where X is NCH3, NH, S or O, but is other than NCH3 when R<6> and R<7> together form -O-, each A, Y and Z, independently, is NR<4>, S or O and R<4> is H, C1-5 alkyl or C6-12 aryl) have analgesic activity.
Inventors:
Gaster, Laramie Mary
Keith Raymond, Mulholland
Keith Raymond, Mulholland
Application Number:
JP50961693A
Publication Date:
March 12, 1996
Filing Date:
October 12, 1993
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/335; A61K31/35; A61K31/352; A61K31/38; A61K31/381; A61K31/382; A61K31/443; A61K31/4433; A61K31/445; A61K31/485; A61P1/00; C07D333/52; A61P9/00; A61P43/00; C07D221/28; C07D311/80; C07D313/12; C07D335/06; C07D401/12; C07D405/12; C07D409/12; C07D413/12; C07D489/00; C07D489/08; (IPC1-7): C07D405/12; A61K31/335; A61K31/35; A61K31/38; A61K31/445; C07D311/80; C07D313/12; C07D333/52; C07D335/06; C07D409/12; C07D413/12
Domestic Patent References:
| JPH01149788A | 1989-06-12 | |||
| JPS61271275A | 1986-12-01 | |||
| JPS574991A | 1982-01-11 | |||
| JPS53119899A | 1978-10-19 | |||
| JPH02121993A | 1990-05-09 | |||
| JPS62258380A | 1987-11-10 | |||
| JPS4732998B1 | ||||
| JPS4118826B1 |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)