Title:
【発明の名称】5-HT▲下4▼レセプターアンタゴニスト用イミダゾピリジン誘導体
Document Type and Number:
Japanese Patent JPH08502274
Kind Code:
A
Abstract:
Compounds of formula (I), and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen or halo; Y is O or NH; Z is of sub-formula (i), (ii), (iii), (iv) or (v), or wherein the piperidine ring in (i) or (ii) is replaced by pyrrolidinyl and/or the N-substituent in (i) or (ii) is replaced by R3 wherein R3 is hydrogen or C1-12alkyl, aralkyl or R3 is (CH2)r-R10 wherein r is 2 or 3 and R10 is selected from cyano, hydroxyl, C1-6alkoxy, phenoxy, C(O)C1-6alkyl, COC6H5, -CONR11R12, NR11COR12, SO2NR11R12 or NR11SO2R12 wherein R11 and R12 are hydrogen or C1-6alkyl; or a compound of formula (I) wherein the CO-Y linkage is replaced by a heterocyclic bioisostere; having 5-HT4 receptor antagonist activity.
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Inventors:
Francis David, King
Gaster, Laramie Mary
Gaster, Laramie Mary
Application Number:
JP50961594A
Publication Date:
March 12, 1996
Filing Date:
October 12, 1993
Export Citation:
Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/435; A61P1/00; A61P9/00; A61P43/00; C07D471/04; C07D519/00; (IPC1-7): C07D471/04; A61K31/435; C07D519/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)
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