Title:
【発明の名称】α-アリール‐γ‐ブチロラクトンの製造方法
Document Type and Number:
Japanese Patent JPH08503939
Kind Code:
A
Abstract:
PCT No. PCT/GB93/02427 Sec. 371 Date May 16, 1995 Sec. 102(e) Date May 16, 1995 PCT Filed Nov. 25, 1993 PCT Pub. No. WO94/12487 PCT Pub. Date Jun. 9, 1994This appliciation discloses a process for preparing a lactone of general formula (I), where R is an optionally substituted phenyl group or an optionally substituted mono- or bicyclic heteroaryl radical which process comprises reacting an anion of a malonate of formula (II) with an ethylene compound of formula (III) Y-CH2-CH2OZ, to give a compound of formula (IV) and hydrolysing the compound of formula (IV) to give a lactone of formula (I). The lactones are of use as intermediates for preparing 5-HT1A binding agents. (I) (II) (IV)
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Inventors:
Robin Gerald, Shepherd
Application Number:
JP51291594A
Publication Date:
April 30, 1996
Filing Date:
November 25, 1993
Export Citation:
Assignee:
John Weiss and Brother Limited
International Classes:
C07D295/20; C07D307/33; C07D315/00; (IPC1-7): C07D307/33
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)