Title:
【発明の名称】置換2-アミノテトラリン
Document Type and Number:
Japanese Patent JPH09501434
Kind Code:
A
Abstract:
Optically active or racemic compounds represented by the formula where R2 is OA and R3 is selected from the group consisting of H and OA; where A is H or is selected from the group consisting of hydrocarbyl radicals comprising between 1 and 3 carbon atoms, as well as with the proviso that when R3 is OA, then R2 and R3 may be bonded together to form the group R4 is selected from the group consisting of alkyl and aromatic residues having from 1 to 20, preferably from 1 to 12, carbon atoms, for example, alkyl, optionally substituted with aromatic residues, and aromatic residues optionally substituted with alkyl radicals; n is an integer from 1 to 4; R5 is an unbranched alkyl chain comprising from 1 and 3 carbon atoms or a cyclopropylmethyl radical; R1 is alkoxy, cycloalkoxy and a cyclic ether of the formula where m is an integer from 3 to 5; with the proviso that when R1 is alkoxy, then R3 cannot be H; and pharmaceutically-acceptable salts thereof. These compounds are useful for alleviating Parkinsonism, glaucoma, hyperprolactinemia and for inducing weight loss in mammals.
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Inventors:
Three Bee, Mark C.
Minascanian, Geborg
Mouzes, El Meredith
Minascanian, Geborg
Mouzes, El Meredith
Application Number:
JP50653195A
Publication Date:
February 10, 1997
Filing Date:
August 05, 1994
Export Citation:
Assignee:
Discovery, Therapeutics, Incorporated
International Classes:
C07D317/58; A61K31/215; A61K31/34; A61K31/341; A61K31/35; A61K31/351; A61K31/357; A61K31/36; A61P25/00; A61P27/02; A61P27/06; C07C217/08; C07C217/12; C07C219/26; C07D307/14; C07D309/04; C07D309/06; C07D317/70; (IPC1-7): C07C217/08; A61K31/215; A61K31/34; A61K31/35; A61K31/36; C07D307/14; C07D309/04; C07D317/58
Attorney, Agent or Firm:
Kazuo Sato (2 outside)