Title:
カイメース阻害活性を有するα−１−抗キモトリプシン類似体
Document Type and Number:
Japanese Patent JPH09512422
Kind Code:
A
Abstract:
The invention provides analogues of alpha -1-antichymotrypsin having amino acid substitutions at position 358. alpha -1-antichymotrypsin analogues having amino acid substitutions at positions 356-361 and analogues having amino acid substitutions at positions 356-361 wherein the amino acid at position 358 is substituted are also within the scope of the invention. These analogues exhibit chymase inhibitory activity. Also provided are novel alpha -1-antichymotrypsins having an N-terminal extension of methionine-alanine-serine or alanine-serine. Expression vectors for the production of alpha -1-antichymotrypsins are also provided. The present invention also provides host cells and cell cultures capable of expressing analogues of alpha -1-antichymotrypsin, as well as protein preparations from the host cells. Methods of producing and using the analogues of alpha -1-antichymotrypsin to inhibit chymase activity are also provided.
Inventors:
クーパマン，バリー エス．
シェクター ノーマン
ルービン，ハービー
ワン，ジ メイ
シェクター ノーマン
ルービン，ハービー
ワン，ジ メイ
Application Number:
JP52563695A
Publication Date:
December 16, 1997
Filing Date:
April 29, 1994
Export Citation:
Assignee:
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア
International Classes:
A61K38/55; A61P7/02; A61P9/00; A61P29/00; A61P31/04; C07H21/04; C07K14/81; C12N1/21; C12N5/10; C12N9/99; C12P21/02; C12N15/09; A61K38/00; C12R1/19; (IPC1-7): C12N15/09; A61K38/55; C07K14/81; C12N1/21; C12N5/10; C12N9/99; C12P21/02
Attorney, Agent or Firm:
倉内 基弘 （外１名）