Title:
【発明の名称】1-(2’-デオキシ-2’,2’-ジフルオロ-D-リボフラノシル)-4-アミノピリミジン-2-オン・塩酸塩の製造方法
Document Type and Number:
Japanese Patent JPH10510806
Kind Code:
A
Abstract:
This invention provides a process for preparing gemcitabine hydrochloride which comprises deblocking beta -1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-amin opyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol in an environment essentially free of water; treating the resulting solution with hydrochloric acid and an antisolvent; and recovering the resulting solid gemcitabine hydrochloride.
Inventors:
Bergland, Richard Alan
Application Number:
JP51883595A
Publication Date:
October 20, 1998
Filing Date:
November 14, 1995
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
C07H19/06; C07H19/073; (IPC1-7): C07H19/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)