Document Type and Number:
Japanese Patent JPS6156236
Kind Code:
B2
Abstract:
NEW MATERIAL:The compound of formula I (Y is O or S; R1, R2 and R3 are H, lower alkoxy, halogen or OH; R4 is H, lower alkoxycarbonyl, lower alkyl, etc.). EXAMPLE:1-Ethoxycarbonyl-8-oxo-1-aza-11a-oxa-C-homoerythrinan. USE:An analgesic having low toxicity and excellent analgesic effect. PREPARATION:The compound of formula I can be prepared by condensing the 3-piperidone derivative of formula II (R7 and R8 are lower alkyl) with the amine of formula III in an inert solvent such as toluene under heating, and cyclizing the product by heating under acidic condition in the presence of a polyphosphoric acid, etc., at 30-250 deg.C.
Inventors:
MURAI HIROSHI
MATSUMURA SHINGO
MORITA IWAO
SUNO KENJI
ENOMOTO HIROSHI
KIMURA KYOSHI
KIMURA YUTAKA
MATSUMURA SHINGO
MORITA IWAO
SUNO KENJI
ENOMOTO HIROSHI
KIMURA KYOSHI
KIMURA YUTAKA
Application Number:
JP18444585A
Publication Date:
December 01, 1986
Filing Date:
August 21, 1985
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD
International Classes:
C07D498/20; A61K31/535; A61K31/54; A61K31/55; A61P25/00; A61P25/04; C07D209/00; C07D221/00; C07D267/00; C07D281/00; C07D513/20
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