Title:
【発明の名称】プソイドモナス アエルギノサ 外毒素Aに対する保護用ヒトモノクロ-ナル抗体
Document Type and Number:
Japanese Patent JPS63500035
Kind Code:
A
Abstract:
Cell lines have been produced that secrete human monoclonal antibodies capable of binding to and neutralizing Pseudomanas aeruginosa exotoxin A. These antibodies have been found to be protective against lethal challenges of the exotoxin. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.
Inventors:
Seeduck, Antony W
Marc Yi, Rostrom
Marc Yi, Rostrom
Application Number:
JP50337186A
Publication Date:
January 07, 1988
Filing Date:
June 02, 1986
Export Citation:
Assignee:
The Generating Systems Co-Poration
International Classes:
A61K39/00; C07K14/005; C07K14/195; C07K14/41; C07K16/00; C12N15/00; C07K16/12; C12N5/00; C12N5/10; C12N15/02; C12P21/00; C12P21/08; A61K38/00; C12R1/91; (IPC1-7): A61K39/395; C07K15/04; C12N5/00; C12N15/00; C12P21/00; C12R1/91
Domestic Patent References:
| JPS58201723A | 1983-11-24 | |||
| JPS61204200A | 1986-09-10 |
Foreign References:
| WO1985001659A1 | 1985-04-25 |
Attorney, Agent or Firm:
Aoki Akira