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Title:
11 ALPHA-AMINO-ANDROSTANE COMPOUND
Document Type and Number:
Japanese Patent JPS57203099
Kind Code:
A
Abstract:
Compounds of the formula …… wherein… R<1> is a C1-8 alkyl group or a C3-7 cycloalkyl group;… R<2> is a hydrogen atom, a C1-6 alkoxy group or a C2-5 alkanoyloxy group;… R<3> is a C1-6 alkyl group of a C3-7 cycloalkyl group; and… R<4> is a group -OR<5> or -OCOR<6> where… R<5> is an alkyl or alkenyl group which may contain up to 6 carbon atoms (or such a group substituted by halogen, C1-6 alkoxy, carboxy, phenyl, phenyl substituted by nitro, halo, C1-4 alkoxy or C1-4 alkyl), a C3-7 cycloalkyl group, a phenyl group (or such a group substituted by nitro, halo, C1-4 alkoxy or C1-4 alkyl), or a carbon-attached 5-7 membered heterocyclic ring in which the heteroatom is selected from nitrogen, oxygen and sulphur, and… R<6> is a hydrogen atom or a group R<5> as defined above;… provided that when the compounds contain a 5 beta -hydrogen atom, R<2> is a hydrogen atom;… and the D-homo analogues thereof having the group -CO2R<3> (wherein R<3> is as defined above) at the 17a beta -position, and salts thereof have activity as antidysthythmic agents and may be applicable for the treatment of dysrhythmias in humans or animals. The compounds may be provided in the form of compositions in admixture with pharmaceutical carriers and excipients and may be prepared by a variety of processes known for producing steroids of this type. The invention also provides intermediates for the preparation of the compounds of formula (I), in which intermediates R<1> and/or R<2> is replaced by a hydrogen atom, and processes for the preparation of such intermediates.

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Inventors:
GOODON HANREI FUIRITSUPUSU
DEIBITSUDO SEDORITSUKU HANBAA
JIYOOJI BURANCHI YUUAN
BARII ANTONII KUUMAA
Application Number:
JP8999582A
Publication Date:
December 13, 1982
Filing Date:
May 28, 1982
Export Citation:
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Assignee:
GLAXO GROUP LTD
International Classes:
A61K31/56; A61P9/06; C07J41/00; C07J63/00; (IPC1-7): A61K31/56; C07J41/00



 
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