Title:
１８Ｆ標識葉酸
Document Type and Number:
Japanese Patent JP5693950
Kind Code:
B2
Abstract:
The present invention is directed towards new 18F-folate radiopharmaceuticals, wherein the fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their precursors and their non-radioactive references, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.
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Inventors:
Atamey Simon Menzer
Moser Rudolph
Los Tobias Ludwig
Grain viola
Moser Rudolph
Los Tobias Ludwig
Grain viola
Application Number:
JP2010502520A
Publication Date:
April 01, 2015
Filing Date:
April 11, 2008
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
International Classes:
C07D475/04; A61K31/519; A61K51/00; C07B59/00; G01N33/48; G01N33/60; G01T1/161
Foreign References:
| WO2004071463A1 | ||||
| WO2006071754A1 |
Other References:
COSULICH,D.B. et al,Journal of the American Chemical Society,1953年,Vol.75,p.4675-4680
NAKAMURA,M. et al,Biochemical and Biophysical Research Communications,2002年,Vol.297,p.1238-1244
MONTGOMERY,J.A. et al,Journal of Medicinal Chemistry,1965年,Vol.8, No.5,p.727-728
BARTLETT,M.S. et al,Antimicrobial Agents and Chemotherapy,1995年,Vol.39, No.11,p.2436-2441
HENKIN,J. et al,Journal of Medicinal Chemistry,1983年,Vol.26, No.8,p.1193-1196
BETTIO,A. et al,Journal of Nuclear Medicine,2006年,Vol.47, No.7,p.1153-1160
NAKAMURA,M. et al,Biochemical and Biophysical Research Communications,2002年,Vol.297,p.1238-1244
MONTGOMERY,J.A. et al,Journal of Medicinal Chemistry,1965年,Vol.8, No.5,p.727-728
BARTLETT,M.S. et al,Antimicrobial Agents and Chemotherapy,1995年,Vol.39, No.11,p.2436-2441
HENKIN,J. et al,Journal of Medicinal Chemistry,1983年,Vol.26, No.8,p.1193-1196
BETTIO,A. et al,Journal of Nuclear Medicine,2006年,Vol.47, No.7,p.1153-1160
Attorney, Agent or Firm:
Mitsufumi Esaki
Blacksmith
Katsunori Uenishi
Ichiro Torayama
Blacksmith
Katsunori Uenishi
Ichiro Torayama