Title:
2-SUBSTITUTED IMIDAZOLE COMPOUND
Document Type and Number:
Japanese Patent JPS5753466
Kind Code:
A
Abstract:
NEW MATERIAL:A 2-substituted imidazole compound of formula I (R is cyclohexyl, phenyl or pyridyl) or an acid addition selt thereof.
EXAMPLE: 2-[2-(2-Pyridyl)-2-phenylethyl] imidazole dihydrochloride.
USE: Useful as an oral drug for diabetes having hypoglycemic action suitably in a dose of usually 100W750mg/kg for a man.
PROCESS: An imino ether of formula II (R' is lower alkyl) is reacted with diethyl aminoacetoacetal at room temperature to under heating at about 120°C, and hydrochloric acid or hydrobromic acid is added to make the reaction mixture strongly acidic. The reaction mixture is then heated at 100°C for 30min to 1hr to give the compound of formula I.
Inventors:
ISHIKAWA FUMIYOSHI
KAMEDA KINYA
NAKAOKA MINORU
KAMEDA KINYA
NAKAOKA MINORU
Application Number:
JP12874280A
Publication Date:
March 30, 1982
Filing Date:
September 17, 1980
Export Citation:
Assignee:
DAIICHI SEIYAKU CO
International Classes:
C07D233/58; A61K31/415; A61K31/44; A61K31/4427; A61P3/08; C07D401/06; (IPC1-7): A61K31/415; A61K31/44; C07D233/58; C07D401/06