2,4(4,6)ピリミジン誘導体 - JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP

Title:

2,4(4,6)ピリミジン誘導体

Document Type and Number:

Japanese Patent JP5022909

Kind Code:

B2

Abstract:

The present invention is drawn to intermediates relating to 2,4 (4,6) pyrimidine derived macrocycles, pharmaceutical compositions thereof, and methods of making said compounds. The compounds disclosed herein are inhibitors of EGF receptor tyrosine kinases and are useful for treating cell proliferative disorders, including atherosclerosis, restenosis, and cancer.

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Inventors:

Frenu, Eddie Jean-Edgar
Willems, Marc
Emblehs, Berner Constant Johann
Van Emmelen, Christoph
Van Brandt, Sfuen Franciscus Anna
Ron boots, Frederik Jiang Rita

Application Number:

JP2007544917A

Publication Date:

September 12, 2012

Filing Date:

December 08, 2005

Export Citation:

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Assignee:

JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP

International Classes:

C07D487/08; A61K31/505; A61K31/5377; A61P9/10; A61P35/00; A61P43/00; C07D239/48; C07D403/12; C07D413/12; C07D487/18; C07D498/08; C07D498/18

Foreign References:

WO2003078404A1
WO2001064655A1
WO2000039101A1
WO2000012485A1
WO2004014382A1

Attorney, Agent or Firm:

Patent business corporation Odashima patent office

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