3-AZINOMETHYL RIFAMYCIN

Title:

3-AZINOMETHYL RIFAMYCIN

Document Type and Number:

Japanese Patent JPS60237089

Kind Code:

A

Abstract:

There are provided 3-azinomethyl rifamycins of the for- mulal:whereinR represents hydrogen or acetyl;R₁ represents hydrogen or lower alkyl;R₂ represents an alkyl group having from 2 to 4 carbon atoms substituted by a dialkoxy group each having from 1 to 3 carbon atoms;R₃ represents an alkyl group having from 1 to 4 carbon atoms;R₂ and R₃ may form with the amino nitrogen atom a 4- to 8- membered heterocyclic ring, having a maximum of two hetero atoms, substituted by hydroxy-, alkoxy-, dialkoxy- or alkylenedioxy groups each having from 1 to 4 carbon atoms, arylalkoxyimino groups having from 7 to 9 carbon atoms, acyloxy groups having from 1 to 4 carbon atoms;R₁ and R₂ may form with the amino nitrogen atom and the carbon atom a 5 to 7-membered heterocyclic ring optionally substituted by alkyl or alkoxy group having from 1 to 4 carbon atoms.The compounds display antibacteria activity against Gram-positive and Gram-negative bacteria and Mycobacteria.Process for the preparation of the above compounds and their pharmaceutical compositions are also described and claimed.

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Inventors:

REONARUDO MARUSHIRI
MARUKO FUARUCHIANI
RENATO BUROTSUJI

Application Number:

JP6988385A

Publication Date:

November 25, 1985

Filing Date:

April 02, 1985

Export Citation:

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