Title:
4-イミダゾリル-1,2,3,4-テトラヒドロキノリン誘導体、およびアルドステロン/11-ベータ-ヒドロキシラーゼ阻害剤としてのその使用
Document Type and Number:
Japanese Patent JP2010513558
Kind Code:
A
Abstract:
The present invention provides a compound of formula I: said compound is inhibitor of aldosterone synthase, and/or 11beta-hydroxylase (CYP11B1), and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase and/or CYP11B1. Finally, the present invention also provides a pharmaceutical composition.
Inventors:
Fu Ki-in
Gary Michael Xander
Gary Michael Xander
Application Number:
JP2009543095A
Publication Date:
April 30, 2010
Filing Date:
December 14, 2007
Export Citation:
Assignee:
Novartis Age
International Classes:
C07D401/04; A61K31/4709; A61K31/5377; A61K31/541; A61P3/00; A61P3/04; A61P3/12; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P17/00; A61P43/00; C07D413/14; C07D417/04
Domestic Patent References:
| JPS60501953A | 1985-11-14 | |||
| JPS62246570A | 1987-10-27 | |||
| JPS62246570A | 1987-10-27 |
Foreign References:
| WO2007117982A2 | 2007-10-18 | |||
| WO2002022585A1 | 2002-03-21 |
Other References:
JPN5009018858; ＵＬＭＳＣＨＮＥＩＤＥＲ: ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ＬＥＴＴＥＲＳ Ｖ１６ Ｎ１, 20060101, Ｐ２５-３０
JPN5009018859; ＭＵＥＬＬＥＲ-ＶＩＥＩＲＡ: ＪＯＵＲＮＡＬ ＯＦ ＳＴＥＲＯＩＤ ＢＩＯＣＨＥＭＩＳＴＲＹ ＡＮＤ ＭＯＬＥＣＵＬＡＲ ＢＩＯＬＯＧＹ Ｖ９６ Ｎ３-４, 20050801, Ｐ２５９-２７０, ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ ＬＴＤ
JPN5009018859; ＭＵＥＬＬＥＲ-ＶＩＥＩＲＡ: ＪＯＵＲＮＡＬ ＯＦ ＳＴＥＲＯＩＤ ＢＩＯＣＨＥＭＩＳＴＲＹ ＡＮＤ ＭＯＬＥＣＵＬＡＲ ＢＩＯＬＯＧＹ Ｖ９６ Ｎ３-４, 20050801, Ｐ２５９-２７０, ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ ＬＴＤ
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa