Title:
4-[17β-メトキシ-17α-メトキシメチル-3-オキソエストラ-4,9-ジエン-11β-イル]ベンズアルデヒド(E)-オキシム(アソプリスニル)の調製方法
Document Type and Number:
Japanese Patent JP2009534345
Kind Code:
A
Abstract:
The present invention relates to a method for the reliable and reproducible preparation of 4-[17ß-methoxy-17a-methoxymethyl-3-oxoestra-4,9-dien-llß- yl]benzaldehyde (E)-oxime (asoprisnil) on the pilot and manufacturing scale. Asoprisnil, which is prepared by this method, is distinguished by a very good physical stability and is therefore particularly suitable for the manufacture of solid pharmaceutical forms (tablets, coated tablets, etc.).
Inventors:
Grave, De Treff
Greezin, Zabine
Gerecke, hagen
Hazel, peter
Muller, Ube
Michel, Thomas
Robert Irells
Kunabe, Ube
Erhard, Bernd
Moses Baja, Michael
Voigtrender, Darphite
Wolf, Tilstham
Jäkke, Jürgen
Crow, crow
Ballman, wolf
Boehmeer, dieter
Michael, Zander
Greezin, Zabine
Gerecke, hagen
Hazel, peter
Muller, Ube
Michel, Thomas
Robert Irells
Kunabe, Ube
Erhard, Bernd
Moses Baja, Michael
Voigtrender, Darphite
Wolf, Tilstham
Jäkke, Jürgen
Crow, crow
Ballman, wolf
Boehmeer, dieter
Michael, Zander
Application Number:
JP2009505800A
Publication Date:
September 24, 2009
Filing Date:
April 17, 2007
Export Citation:
Assignee:
Bayer Schering Pharma Aktiengesellschaft
International Classes:
C07C249/08; A61K9/20; A61K31/567; A61P5/24; A61P15/00; C07C249/14; C07C251/48; C07B61/00; C07J41/00
Domestic Patent References:
| JP2003040826A | 2003-02-13 | |||
| JPH0248598A | 1990-02-19 | |||
| JP2004513179A | 2004-04-30 | |||
| JP2003534350A | 2003-11-18 | |||
| JP2004513178A | 2004-04-30 |
Other References:
JPN5009005561; ＬＩＵ Ａ: ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ３５ Ｎ１１, 19920529, Ｐ２１１３-２１２９, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Masaru Nakajima