Title:
The 4th place or the chondroitin sulfate sulfurated in biotechnology by the 6th place of the same many sugar chains, and an adjustment method for the same
Document Type and Number:
Japanese Patent JP6205350
Kind Code:
B2
Abstract:
The present invention discloses a process for the production of chondroitin sulphate with an average molecular weight (Mw) of 10-30 kDa by chemical sulphation starting from an unsulphated chondroitin backbone, obtained in turn by acid hydrolysis of capsular polysaccharide K4 made directly from E. coli strain O5:K4:H4, or directly produced from a genetically modified strain of E. coli. Sulphation of the N-acetyl-D-galactosamine residue at position 4 or 6 takes place simultaneously in the same polysaccharide chain, simulating the sulphation pattern observed in natural chondroitin sulphate, unlike the sulphation obtained with the synthesis methods described to date.
More Like This:
Inventors:
Bianchi, David
Valetti, Marco
Badza, Paola
Miglia, Niccolo
Valotti, Ermanno
Valetti, Marco
Badza, Paola
Miglia, Niccolo
Valotti, Ermanno
Application Number:
JP2014509734A
Publication Date:
September 27, 2017
Filing Date:
May 10, 2012
Export Citation:
Assignee:
GNOSIS S.P.A.
International Classes:
C08B37/08
Domestic Patent References:
| JP61047701A | ||||
| JP2007091662A | ||||
| JP2010530896A | ||||
| JP60224065A |
Foreign References:
| EP1304338A1 | ||||
| WO2009149155A1 |
Other References:
生化学辞典(第3版),株式会社東京化学同人,1998年11月20日,p.556-557
糖化学の基礎,株式会社講談社,1995年 8月10日,p.152-154
Carbohydrate Research,1994年,Vol.255,p.41-59
Journal of Pharmaceutical Sciences,2007年,p.3168-3180
Biomaterials,2002年,Vol.23,p.3015-3022
今日の治療薬(2003年版),株式会社南江堂,2003年 2月15日,p.929
糖化学の基礎,株式会社講談社,1995年 8月10日,p.152-154
Carbohydrate Research,1994年,Vol.255,p.41-59
Journal of Pharmaceutical Sciences,2007年,p.3168-3180
Biomaterials,2002年,Vol.23,p.3015-3022
今日の治療薬(2003年版),株式会社南江堂,2003年 2月15日,p.929
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata