Title:
5-FLUOROURIDINE DERIVATIVE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPS6081197
Kind Code:
A
Abstract:
NEW MATERIAL:A high-molecular weight 5-fluorouridine derivative of formula I (n≥2) and a salt thereof.
USE: A carcinostatic agent having improved prolonged release properties of the 5- fluorouridine and low toxicity.
PREPARATION: Divinyl ether-maleic anhydride copolymer of formula II is reacted with 5-fluorouridine of formula III in the presence of an organic solvent, e.g. N-methylpyrrolidone, and the resultant reaction product is then hydrolyzed. Substances other than the aimed substance are then removed by ultrafiltration, etc., and the resultant reaction product is freeze-dried, etc. to afford the aimed compound of formula I . The content of the 5-fluorouridine in the resultant high- molecular weight derivative is preferably 5W40wt%.
Inventors:
OOHASHI SHINICHI
HIRANO TAKASHI
SHIRAKI MASARU
MORIMOTO SATOSHI
TSUDA KEISHIROU
KOBAYASHI TOMOO
TSUKAGOSHI SHIGERU
HIRANO TAKASHI
SHIRAKI MASARU
MORIMOTO SATOSHI
TSUDA KEISHIROU
KOBAYASHI TOMOO
TSUKAGOSHI SHIGERU
Application Number:
JP19178883A
Publication Date:
May 09, 1985
Filing Date:
October 13, 1983
Export Citation:
Assignee:
KOGYO GIJUTSUIN
International Classes:
C08F8/00; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61K47/48; A61P35/00; C07H19/06; C08F8/30; C08F20/00; C08F20/02; C08F216/12; C08F222/06; (IPC1-7): A61K31/70; C07H19/06; C08F8/30; C08F216/12; C08F222/06
Domestic Patent References:
| JPS58176832A | 1983-10-17 |
Attorney, Agent or Firm:
Director, Institute of Textile and Polymer Materials, AIST