Polypeptide which contains in the human respiratory syncytial virus (hRSV) for prevention of respiratory tract infection, and/or medical treatment the improvement amino acid sequence and this which have directivity

Title:

Document Type and Number:

Japanese Patent JP6081196

Kind Code:

B2

Abstract:

Amino acid sequences are provided that are directed against/and or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.

Inventors:

Depra, Erik
Stotherers, Katerine
Stepheny, Stephanie

Application Number:

JP2012513641A

Publication Date:

March 01, 2017

Filing Date:

June 07, 2010

Export Citation:

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Assignee:

Abrinks En.

International Classes:

C12N15/09; A61K38/16; A61K48/00; A61P11/00; A61P11/06; A61P31/14; C07K16/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10

Domestic Patent References:

JP2011521662A

Other References:

CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY,2008年,vol. 317,pp. 103-123
PEDIATRIC INFECTIOUS DISEASE JOURNAL,2009年 4月,vol. 28, no. 4,pp. 267-272
Journal of Molecular Biology,2007年,vol. 368,pp. 652-665

Attorney, Agent or Firm:

Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga

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