Title:
6-HETEROCYCLE-4-AMINO-1, 2, 2A, 3, 4, 5- HEXAHYDROBENZ(CD)INDOLES FOR TREATING MOTION SICKNESS AND VOMITION
Document Type and Number:
Japanese Patent JPH06211654
Kind Code:
A
Abstract:
PURPOSE: To obtain a new compd. having selective affinity for the 5-HT receptor of a brain and much smaller affinity for other receptor and useful to treat motion sickness and emesis. CONSTITUTION: This compd. is represented by formula 1, wherein R<1> is H, a 1-4C alkyl, 3-4C alkenyl, cyclopropylmethyl, aryl-1-4C alkyl, (CH2 )n S-1 to 4C alkyl, CO-R<4> or (CH2 )n -CO-NR<5> R<6> (1<=n<=4, R<4> is H, an alkyl, haloalkyl, alkoxy or phenyl, each of R<5> and R<6> is H, an alkyl or cycloalkyl, but when one of R<5> and R<6> is a cycloalkyl, the other is H), R<2> is H, a 1-4C alkyl, cyclopropylmethyl or 3-4C alkenyl, R<3> is H, a 1-4C alkyl or an amino protective group, HET is (substd.) tetrazolyl or an arom. 5- or 6-membered heterocyclic group having 1-3 hetero atoms (O, N, S). It is, e.g. 6-(2-oxazolyl)-4-(di-n- propylamino)-1,2,2a,3,4,5-hexahydrobenz[cd]indole.
More Like This:
Inventors:
RICHIYAADO NOORAN BUUHAA
MAIKERU EDOWAADO FUROO
DEIBITSUDO AANESUTO ROOHOON
MAIKERU JIYON MAATEINERI
CHIYAARUZU JIYONSON PAJIETSUTO
JIYON MENAATO SHIYAUSU
MAIKERU EDOWAADO FUROO
DEIBITSUDO AANESUTO ROOHOON
MAIKERU JIYON MAATEINERI
CHIYAARUZU JIYONSON PAJIETSUTO
JIYON MENAATO SHIYAUSU
Application Number:
JP24260693A
Publication Date:
August 02, 1994
Filing Date:
September 29, 1993
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/425; A61P1/04; C07D403/02; A61P1/06; A61P9/12; A61P25/06; A61P25/22; A61P25/24; A61P43/00; C07D209/40; C07D209/90; C07D401/04; C07D403/04; C07D405/04; C07D409/04; C07D413/04; C07D417/04; C07D419/04; (IPC1-7): A61K31/40; A61K31/425; C07D403/04; C07D409/04; C07D413/04; C07D417/04
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)