セリンプロテアーゼ抑制剤として有用な酸誘導体

Title:

セリンプロテアーゼ抑制剤として有用な酸誘導体

Document Type and Number:

Japanese Patent JP2004517060

Kind Code:

A

Abstract:

Compounds of formula I and II,or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is a linker, and R1-R27, W, Z1, and Z2 are as defined in the specification.

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Inventors:

Besatch, Gregory S
Sutton, James Sea Junior
Woo, shansea

Application Number:

JP2002540539A

Publication Date:

June 10, 2004

Filing Date:

November 07, 2001

Export Citation:

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Assignee:

Bristol-Myers Squibb Company

International Classes:

A61K31/192; A61K31/402; A61K31/4458; A61K31/4545; A61K31/55; A61K45/00; A61K45/06; A61P7/02; A61P29/00; A61P37/00; C07C257/18; C07D207/16; C07D211/60; C07D223/06; C07D401/12; (IPC1-7): C07C257/18; A61K31/192; A61K31/402; A61K31/4458; A61K31/4545; A61K31/55; A61K45/00; A61P7/02; A61P29/00; A61P37/00; C07D207/16; C07D211/60; C07D223/06; C07D401/12

Attorney, Agent or Firm:

Takehiko Saito
Yasuyuki Hata

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