ACTIVE SILK MUCO-ADHESIVE, SILK ELECTROGELATION PROCESS, AND DEVICE

Japanese Patent JP2015212254

A

PROBLEM TO BE SOLVED: To provide a composition, a method and a device for rapidly converting silk fibroin solution into silk fibroin gel.SOLUTION: Silk fibroin gel produced by applying electric field to solubilized silk fibroin solution is reversibly converted into a liquid form by applying reverse voltage, or converted further into a β-sheet structure by applying a shear force or other treatment. Electrogelated silk converted by the process above exists as a piezoelectric silk material comprising a mixture of silk I conformation and silk fibroin protein having a silk β- sheet structure, and a silk electrogelation process is useful in various applications such as tissue engineering, medical device or implant, drug delivery, or technique related to soft robotics.

JPH11215983	ANTIFUNGAL AGENT WITH PEPTIDE AS ACTIVE COMPONENT
JP2009011316	FLUORESCENT PROTEIN AND METHOD FOR USING THE SAME
WO/2012/037370	TREATMENT OF CHRONIC NEPHROPATHIES USING SOLUBLE COMPLEMENT RECEPTOR TYPE I (SCR1)

NICOLAI N BERNHARD
TIM JIA-CHING LO
GARY G LEISK
KAPLAN DAVID L

JP2015070744A

November 26, 2015

March 31, 2015

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TUFTS COLLEGE

C07K14/435; A23L1/305; A61C8/00; A61F2/06; A61K6/00; A61K6/884; A61K9/06; A61K38/17; A61K47/42; A61L17/00; A61L27/00; A61L31/00; A61L33/00; A61P17/02; C08J3/24

JP2007515391A	2007-06-14
JPH04263611A	1992-09-18
JP2008502739A	2008-01-31

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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