Title:
ACTIVE TYPE VITAMIN D DERIVATIVE
Document Type and Number:
Japanese Patent JP3108474
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new active type vitamin D derivative useful as an agent for osteoporosis, an agent for skin ulcer and an antitumor agent.
CONSTITUTION: An active type vitamin D derivative shown by formula I or formula II (R is group shown by formula III or formula IV) such as 1α- hydroxycholecalciferol vitamin A acid (whole trans type ester. These compounds are obtained by protecting hydroxyl group at the 3-position of a compound shown by formula V obtained from vitamin D3 and vitamin D2 by four processes, then hydrolyzing acetoxy group at the 1-position to give a compound shown by formula VI (X is protecting group), then subjecting this compound to ester condensation with whole trans-vitamin A acid (whole trans-retinoic acid shown by formula VII or 13-cis-vitamin A acid (13-cis-retinoic acid) shown by formula VIII, and finally eliminating protecting group of hydroxyl group at the 3-position.
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Inventors:
Yoji Tachibana
Application Number:
JP19761291A
Publication Date:
November 13, 2000
Filing Date:
August 07, 1991
Export Citation:
Assignee:
NISSHIN FLOUR MILLING CO.,LTD.
International Classes:
A61K31/59; A61P3/02; A61P17/00; A61P17/02; A61P19/10; A61P35/00; A61P43/00; C07C403/20; (IPC1-7): C07C403/20; A61K31/59; A61P17/02; A61P19/10; A61P35/00
Domestic Patent References:
| JP63255229A | ||||
| JP58162517A | ||||
| JP5195123A | ||||
| JP48469A | ||||
| JP5492967A | ||||
| JP4244058A |
Attorney, Agent or Firm:
Chika Takagi (2 outside)