PURPOSE: To use a perfluorocarbon compound emulsion well-known as a transfusion for transporting oxygen as an adminiculum for chemotherapy of cancers for increasing effect of a carcinostatic agent, by using it with the carcinostatic agent.
CONSTITUTION: A perfluorocarbon compound emulsion is used as an adminiculum for chemotherapy of cancers. The fluorocarbon emulsion as a transfusion [Fluosol-DA, Midori Juji K.K] is applied to patients of a large amount of hemorrhage. This time it is found to increase extremely carcinostatic properties of a carcinostatic agent by using it together with the carcinostatic agent. The emulsion increases the effect of the carcinostatic agent on the center of tumor having resistance to carcinostatic agent or cells of low oxygen around it. The emulsion transports oxygen to fine blood vessel of tumor cell, and provides the cell of low oxygen with oxygen. It is considered that the effect is resulted from increase in the concentration of the carcinostatic agent caused by prevention of reduction in viscosity of blood, and slenderization of blood capillary.
KOKUUCHI TAKASHI
TAMAKI NORIHIKO
MATSUMOTO SATORU
KAGITANI MASAO
YOKOYAMA KAZUMASA
| JPS59501665A | 1984-10-04 |
| US4366169A | 1982-12-28 |