PURPOSE: To obtain an alanylalaninol derivative expressed by a specific formula, having in vitro proliferation inhibitory activity against mouse lymphatic leukemia cells, thus useful as an antineoplastic agent.
CONSTITUTION: The objective derivative of formula I [R1 and R2 each is (substituted) aromatic group; R3 and R4 each is H, benzyloxycarbonyl, t- butyloxycarbonyl, a (substituted) aromatic group or an aromatic acyl, when one party of R1 and R2 is nonsubstituted phenyl, the other being a group except nonsubstituted phenyl]. This derivative is recommended to obtain, for example, by the following processes: an N-t-butoxycarbonyl-alanine derivative of formula II is reacted with an alaninol derivative of formula III in the presence of a condensation agent and an auxiliary thereof followed by reaction with e.g. an acid anhydride in the presence of a base to effect acylation followed by treatment with trifluoroacetic acid and then acylation.
| WO/2022/263605 | FRAGRANCE COMPOUNDS |
| JP2514901 | PREPARATION OF CRYSTAL FORM-1 RANITIDINE HYDROCHLORIDE |
YAMADA AKIHIRO
YAMADA KAORU
