Title:
好中球のIL-8誘発走化性の阻害に有用なアミド
Document Type and Number:
Japanese Patent JP4937479
Kind Code:
B2
Abstract:
N-(2-aryl-propionyl)-amides of formula (I) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of N-(2-aryl-propionyl)amides of formula (I) for use in the inhibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.
More Like This:
Inventors:
Alegretti, Marcello
Riccardo, Bertini
Chinzia, Bizzalli
Sabbatini, Vilma
Casselli, Jean Franco
Sesta, Maria Candida
Gandolfi, Carmelo
Colotta, Francesco
Riccardo, Bertini
Chinzia, Bizzalli
Sabbatini, Vilma
Casselli, Jean Franco
Sesta, Maria Candida
Gandolfi, Carmelo
Colotta, Francesco
Application Number:
JP2001558404A
Publication Date:
May 23, 2012
Filing Date:
February 06, 2001
Export Citation:
Assignee:
Dompe Fa.le.Ma Sochieta per Azioni
International Classes:
C07C233/51; A61K31/12; A61K31/16; A61K31/165; A61K31/197; A61K31/221; A61K31/223; A61K31/4035; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/495; A61K31/4965; A61K31/505; A61P1/04; A61P9/10; A61P11/00; A61P13/12; A61P17/06; A61P19/02; A61P21/02; A61P29/00; C07C51/353; C07C57/42; C07C59/52; C07C69/157; C07C233/11; C07C233/22; C07C233/52; C07C235/34; C07C235/78; C07C237/20; C07C259/06; C07C271/64; C07D209/46; C07D213/75; C07D233/61; C07D239/42; C07D241/28; C07D409/12; C07K5/06; A61K38/00
Domestic Patent References:
| JP2101041A | ||||
| JP54141754A | ||||
| JP61289057A | ||||
| JP57042663A | ||||
| JP8500816A | ||||
| JP7149646A |
Other References:
European Journal of Medicinal Chemistry,1984年,19(6),p.567-568
Analytica Chimica Acta,1996年,332(2-3),p.213-224
Journal of Drug Targeting,1995年,2(6),p.517-525
Tetrahedron Letters,1977年,(16),p.1417-1420
Justus Liebigs Annalen der Chemie,1967年,706,p.37-46
Analytica Chimica Acta,1996年,332(2-3),p.213-224
Journal of Drug Targeting,1995年,2(6),p.517-525
Tetrahedron Letters,1977年,(16),p.1417-1420
Justus Liebigs Annalen der Chemie,1967年,706,p.37-46
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita