AMINE DERIVATIVE

Japanese Patent JP3839551

B2

PROBLEM TO BE SOLVED: To obtain the subject new compound having an excellent antifungal activity.
SOLUTION: This amine derivative is a compound of formula I [R1 is a 1-4C alkyl; R2 is a 1-4C alkyl or phenyl; R3 is a 1-3C alkyl, a 1-5C acyl, a halogen, etc.; (k), (l), and (m) are each 1-4], e.g. trans-3'-[N-(4-tert-butylbenzyl)-N- methylaminomethyl]acetophenone. The compound of the formula I is obtained by condensing 0.1-10.0 mol, especially 1.0-2.5 mol secondary amine derivative of formula II with a halogenated compound of formula III (X is a halogen). This condensation reaction is performed by using a condensation reagent such as a tertiary organic amine such as triethylamine, and an inorganic base such as anhydrous potassium carbonate in the presence of a solvent e.g. N,N- dimethylformamide. This compound is excellent in antifungal activity and has a high usefulness as an antifungal agent, an antifungal composition containing the same, and a medicine, etc., containing the same as an active ingredient.

Takao Ito
Takuji Nakajima
Akatsuki Nozawa
Koji Yokoyama
Hiroyuki Takimoto
Masayuki Yuasa
Yukio Kawazu
Toshimitsu Suzuki
Toshiro Mashima

JP13087897A

November 01, 2006

May 21, 1997

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POLA Kasei Kogyo Co., Ltd.

A61K31/135; C07C211/27; A01N33/04; A01N33/08; A01N35/04; A01P3/00; A61P31/04; A61P31/10; C07C209/60; C07C211/35; C07C213/02; C07C215/28; C07C221/00; C07C223/02; C07C225/16; (IPC1-7): C07C211/27; A01N33/04; A01N33/08; A01N35/04; A61K31/135; C07C209/60; C07C211/35; C07C213/02; C07C215/28; C07C221/00; C07C223/02; C07C225/16

JP64006242A
JP62201850A
JP10139740A

Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba

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