Title:
Amino lipid and the delivery method of nucleic acid which were improved
Document Type and Number:
Japanese Patent JP6077509
Kind Code:
B2
Abstract:
The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
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Inventors:
Michael Jay Hope
Shawn Sea. Semple
Tian Sing Chen
Thomas Dee. Madin
Peter Earl. Charis
Marco A. Ciufolini
Barbara Mui
Shawn Sea. Semple
Tian Sing Chen
Thomas Dee. Madin
Peter Earl. Charis
Marco A. Ciufolini
Barbara Mui
Application Number:
JP2014194789A
Publication Date:
February 08, 2017
Filing Date:
September 25, 2014
Export Citation:
Assignee:
Tekmira Pharmaceuticals Corporation
The University of British Columbia
The University of British Columbia
International Classes:
C07C229/12; A61K9/14; A61K31/22; A61K38/00; A61K39/002; A61K39/02; A61K39/12; A61K47/22; A61K47/24; A61K47/28; A61K47/34; A61K48/00; A61P37/04; A61P43/00
Domestic Patent References:
| JP2009143960A | ||||
| JP2010505873A | ||||
| JP2011516586A | ||||
| JP2011509258A |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita