Title:
AMINOSTEROL COMPOUNDS USEFUL AS INHIBITORS OF THE SODIUM/PROTON EXCHANGER (NHE), PHARMACEUTICAL METHODS AND COMPOSITIONS EMPLOYING SUCH INHIBITORS, AND PROCESSES FOR EVALUATING THE NHE-INHIBITORY EFFICACY OF COMPOUNDS
Document Type and Number:
Japanese Patent JP2007314577
Kind Code:
A
Abstract:
To provide specific inhibitors of sodium/proton exchanger (NHE), and to provide NHE inhibitors for various therapeutic uses.
New isolated or synthesized aminosterol compounds such as compound FX1A, compound FX1B, compound 1360, compound 1361, compound 371, compound 1437, and compound 353 or their pharmaceutically acceptable salts, are useful as NHE inhibitors. These steroid compounds include found inhibitors for inhibiting various NHEs and found inhibitors for advantageously inhibiting specific single NHEs, respectively. The structures of these compounds are as shown in the specification.
COPYRIGHT: (C)2008,JPO&INPIT
Inventors:
ZASLOFF MICHAEL
SHINNAR ANN
KINNEY WILLIAM
WILLIAMS JOHN
RAO MEENA
ANDERSON MARK
MCLANE MICHAEL
JONES STEVEN
SHINNAR ANN
KINNEY WILLIAM
WILLIAMS JOHN
RAO MEENA
ANDERSON MARK
MCLANE MICHAEL
JONES STEVEN
Application Number:
JP2007223309A
Publication Date:
December 06, 2007
Filing Date:
August 29, 2007
Export Citation:
Assignee:
GENAERA CORP
International Classes:
A61K31/575; A61P3/00; C07J41/00; A61P3/04; A61P3/10; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P43/00; G01N33/48; G01N33/50
Foreign References:
| US5192756A | 1993-03-09 | |||
| US5192756A | 1993-03-09 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita
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