Title:
ANDROSTENE-17-DITHIOKETALS
Document Type and Number:
Japanese Patent JPS59144800
Kind Code:
A
Abstract:
Topical antiinflammatory activity is exhibited by steroids having the formula and the 1,2-dehydro, and 6,7-dehydro derivatives thereof, wherein one of R1 and R2 is alkyl, aryl, arylalkyl, or cycloalkyl, and the other is alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, mono-, di- or trifluoroalkyl, cyanoalkyl, alkanoylalkyl or wherein n is 1, 2, 3 or 4 and Y1 and Y2 are the same or different and each is hydrogen or alkyl; R3 is hydrogen, hydroxy, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or fluorine; R4 is carbonyl, beta -hydroxymethylene or beta -acetyloxymethylene; R5 is hydrogen or halogen; and R6 is hydrogen, methyl, hydroxy, alkanoyl, alkanoyloxy or halogen.
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Inventors:
VARMA RAVI K
KARANEWSKY DONALD S
KARANEWSKY DONALD S
Application Number:
JP1690884A
Publication Date:
August 18, 1984
Filing Date:
January 30, 1984
Export Citation:
Assignee:
SQUIBB & SONS INC
International Classes:
A61K31/565; A61P29/00; C07J1/00; C07J31/00; C07J41/00; (IPC1-7): A61K31/565; C07J31/00
Attorney, Agent or Firm:
Aoyama