Title:
オキソアニオン結合に基づく抗菌剤
Document Type and Number:
Japanese Patent JP2005504777
Kind Code:
A
Abstract:
Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group consisting of O, NR, and CH2, where R-H or C1-C8 alkyl, or C1-C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.
Inventors:
Stephen Earl Cooper
Craig M. Yager
Craig M. Yager
Application Number:
JP2003522547A
Publication Date:
February 17, 2005
Filing Date:
August 22, 2002
Export Citation:
Assignee:
Qualex Pharmaceuticals Incorporated
International Classes:
C07D317/46; A61K31/33; A61K31/36; A61K31/38; A61K31/381; A61K31/39; A61K31/4184; A61K31/423; A61K31/425; A61K31/433; A61K31/66; A61K31/69; A61P31/04; C07D235/26; C07D263/58; C07D285/14; C07D291/08; C07D327/10; C07D333/72; (IPC1-7): A61K31/33; A61K31/36; A61K31/381; A61K31/39; A61K31/4184; A61K31/423; A61K31/433; A61K31/66; A61K31/69; A61P31/04; C07D235/26; C07D263/58; C07D285/14; C07D291/08; C07D317/46; C07D327/10; C07D333/72
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Masakazu Aoyama
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Masakazu Aoyama
Yasuhiko Murayama
Shinya Mitsuhiro