Title:
ANTIHYPERTENSIVE DIHYDROPYRIDINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS61210071
Kind Code:
A
Abstract:
Novel dihydropyridine derivatives which are useful for treating congestive heart failure, hypertension, or angina have the formula:
or a pharmaceutically acceptable acid addition salt thereof, wherein
n is an integer from 0 to 8;
Y is -O-, -NH-, -NR2-, -S-, -S(O)-, -S(O)2-, or a bond;
R1 and R2 are each independently, A1, A2, A3 or A4 where A1 is -(CH2)m(CHOH)pCH2OH;
A2 is -(CH2)qCH(3-r)[(CH2)sOH]r;
A3 is -(CH2)qCH(3-r)[(CH2)PCOOR3]r; and
A4 is -(CH2)mCOOR3; where
m is an integer from 1 to 8;
p is an integer from 0 to 4;
q is an integer from 0 to 8;
r is 2 or 3;
s is an integer from 1 to 4; and
R3 is H or alkyl of 1 to 18 carbon atoms;
R4 is -NO2, -CF3, or halo; and
R5 is lower alkyl or -CH2CH2OCH3.
Inventors:
ROBIN DAGURASU KURAAKU
MOISHII MAIKERU POBUSHIKOBU
MOISHII MAIKERU POBUSHIKOBU
Application Number:
JP2773586A
Publication Date:
September 18, 1986
Filing Date:
February 10, 1986
Export Citation:
Assignee:
SYNTEX INC
International Classes:
A61K31/4418; A61K31/4422; A61K31/443; A61K31/455; A61P3/00; A61P9/08; A61P9/10; C07D211/82; A61P9/12; C07D211/90; C07D317/00; C07D317/20; C07D317/22; C07D317/24; C07D317/30; C07D319/00; C07D405/12; (IPC1-7): A61K31/455; C07D211/00; C07D211/90; C07D317/00; C07D317/22; C07D319/00; C07D405/12
Attorney, Agent or Firm:
Aoyama Aoi
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