Title:
ドセタキセルおよびアンチセンスオリゴヌクレオチドを含む、抗腫瘍併用療法
Document Type and Number:
Japanese Patent JP2012509878
Kind Code:
A
Abstract:
The present invention provides methods of sensitizing cancer cells to docetaxel and inhibiting the growth of various tumors by employing a modified eIF-4E antisense oligonucleotide and docetaxel in combination.
Inventors:
Graff, Jeremy Richard
Application Number:
JP2011537545A
Publication Date:
April 26, 2012
Filing Date:
November 17, 2009
Export Citation:
Assignee:
Isis Pharmaceuticals, Inc.
International Classes:
A61K31/337; A61K31/712; A61K31/7125; A61K48/00; A61P35/00; A61P43/00; C07D305/14; C07H21/04
Domestic Patent References:
| JP2007505627A | 2007-03-15 |
Other References:
JPN6014002680; Ｎｉｚａｒ Ｍ． Ｍｈａｉｄａｔ， ｅｔ ａｌ．: 'Ｍｅｌａｎｏｍａ ｃｅｌｌ ｓｅｎｓｉｔｉｖｉｔｙ ｔｏ Ｄｏｃｅｔａｘｅｌ-ｉｎｄｕｃｅｄ ａｐｏｐｔｏｓｉｓ ｉｓ ｄｅｔｅｒｍｉｎｅｄ ｂｙ ｃｌａｓｓ ＩＩＩ ｂｅｔａ-ｔｕｂｕｌｉｎ ｌｅｖ' ＦＥＢＳ Ｌｅｔｔ ５８２（２）, 200801, ２６７-７２
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Mitsutoshi Nakamura