APPARATUS AND METHOD FOR GENE DIAGNOSIS

Japanese Patent JP3781686

B2

PROBLEM TO BE SOLVED: To provide an apparatus and a method of the gene diagnosis capable of detecting the gene abnormality of single nucleotide or more in a short time, easily and accurately, and capable of automating the diagnosis with a reduced size, a reduced weight, a low price and a small running cost.
SOLUTION: In the apparatus of the gene diagnosis, there are filled a separation DNA conjugate in which a first base sequence capable of hydrogen bonding with a DNA sample is coupled with a polymeric compound and the DNA sample is separated to a normal DNA and an abnormal DNA by the difference of bonding strength; a delay DNA conjugate in which a second base sequence is coupled with the polymeric compound and only a noise DNA is differentiated by providing the second base sequence with similar bonding strengths to the normal DNA and the abnormal DNA; and the DNA sample. The DNA sample in a closed flow path is electrophoresed by increasing the absolute value of the voltage and a detecting section measures passing quantities of the normal DNA, the abnormal DNA and the noise DNA, respectively.

Takeshi Nishida
Hideaki Hashimoto
Kazuyoshi Mori
Mizuo Maeda
Yoshiki Katayama

JP2002042925A

May 31, 2006

February 20, 2002

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Matsushita Electric Industrial Co., Ltd
Mizuo Maeda
Yoshiki Katayama

G01N27/447; G01N33/50; C12M1/00; C12M1/34; C12M1/38; C12M1/42; C12N15/09; C12Q1/68; G01N33/483; (IPC1-7): G01N33/50; C12M1/00; C12Q1/68; G01N27/447; G01N33/483

JP2001252098A
JP6138090A
JP5332992A

有澤卓己,キャピラリー電気泳動による遺伝子変異診断法の開発,九州大学大学院工学研究科 材料物性工学専攻 前田研究室 卒業論文,日本,2000年 9月
穴田貴久,DNAコンジュゲートを用いる遺伝子一塩基変位診断システムの開発,日本分析化学会第49年会講演要旨集,日本,2000年 9月,p.180

Fumio Iwahashi
Daisuke Nagano
Hiroki Naito

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