BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2

Title:

BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2

Document Type and Number:

Japanese Patent JP2015007124

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods of use thereof.SOLUTION: This invention provides a compound of a structural formula I or salt thereof, where R-Rare independently selected from the group consisting of hydrogen and deuterium; and at least one of R-Ris deuterium.

More Like This:

JP7109360	Valbenazine salts and their polymorphs
JPS6236380	SUBSTITUTED HEXAHYDROARYLQUINOLIDINE
WO/2015/173164	NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

Inventors:

THOMAS G GANT
MANOUCHEHR SHAHBAZ

Application Number:

JP2014185634A

Publication Date:

January 15, 2015

Filing Date:

September 11, 2014

Export Citation:

Click for automatic bibliography generation Help

Assignee:

AUSPEX PHARMACEUTICALS INC

International Classes:

C07D455/06; A61K31/40; A61K31/4515; A61K31/454; A61K31/4745; A61K31/5415; A61K31/551; A61K31/5513; A61K31/5517; A61K31/553; A61K31/554; A61K45/00; A61P1/16; A61P25/14; A61P43/00

Domestic Patent References:

JPH09510717A	1997-10-28
JP2007512339A	2007-05-17
JP2007522193A	2007-08-09
JP5616345B2	2014-10-29

Other References:

JINDAL,S.P. ET AL: "Mass spectrometric determination of tetrabenazine using a stable isotope-labeled analogue as an inte", JOURNAL OF CHROMATOGRAPHY, BIOMEDICAL APPLICATIONS, vol. 493, no. 2, JPN6014001721, 1 September 1989 (1989-09-01), pages 392 - 7, ISSN: 0003102957

Attorney, Agent or Firm:

Yamada Takuji
Aoyama 葆
Michiko Matsutani
Ochiai 康

Previous Patent: EXTERNAL PREPARATION FOR SKIN

Next Patent: CERAMIDE DERIVATIVES AS MODULATORS OF IMMUNITY AND AUTOIMMUNITY